Haley Hieronymus

 

Memorial Sloan Kettering Cancer Center

1275 York Ave Box 20  ·  New York, NY 10065

haley@metaphase.net

 

 

 

EXPERIENCE

 

2008 – present   Senior Scientist, Memorial Sloan Kettering Cancer Center, New York, New York

 

2005 – 2007   Post-doctoral research fellow, Laboratory of Todd Golub, Broad Institute, Massachusetts Institute of Technology and Harvard University

 Research centered on nuclear hormone receptor and kinase signaling in cancer

   

1999 – 2004  Doctoral student, Laboratory of Pamela Silver,  Department of Biological Chemistry and Molecular Pharmacology, Department of Systems Biology, Harvard Medical School

 Ph.D. thesis focused on nuclear transport of mRNA and its integration with gene expression processes

 

1998 – 1999  Undergraduate thesis student, Laboratory of Adele Wolfson, Wellesley College 

Determined the kinetics and mechanism of calcium activation of thimet neuroendopeptidase.

 

1998  Undergraduate research fellow, Laboratory of Vishwanath Lingappa, UCSF

Examined the role and mechanism of apoptosis in heritable neurodegenerative prion disease.

 

 

 

EDUCATION

 

1999 - 2004  Harvard Medical School, Harvard University,  Boston, MA

Ph.D. in Biological and Biomedical Sciences, GPA 3.85

 

1997 – 1998  Oxford University, Oxford, England

Visiting student, Department of Biochemistry, junior year

 

1995 - 1999   Wellesley College,   Wellesley, MA

B.A. in Biological Chemistry with honors, summa cum laude, GPA 3.97

 

 

 

AWARDS AND GRANTS

 

2005                    

Damon Runyon Postdoctoral Fellowship (accepted)

Life Sciences Research Fund Postdoctoral Fellowship

American Cancer Society Postdoctoral Fellowship

NIH Kirschstein NRSA Postdoctoral Fellowship

 

2003                    

Harvard Fellowship finalist

 

1999                    

Howard Hughes Medical Institute Predoctoral Fellowship (accepted)

National Science Foundation Graduate Fellowship

Karin Ippen-Ihler Prize in Chemistry for academic excellence & service

Sigma Xi, national science and engineering honors society

Phi Beta Kappa

 

 

 

PUBLICATIONS

 

Carver BS, Chapinski C, Wongvipat J,  Hieronymus H, Chen Y,  Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL^.  Reciprocal feedback inhibition of the PI3K and androgen receptor pathways in PTEN-deficient prostate cancer predicts sensitivity to combined pathway blockade. Cancer Cell, in press.

 

Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Brown K, Miller VA, Hannon G, Sawyers CL. CD95/Fas and NFκB signaling modulate dependence of lung cancers on mutant

EGFR. Nature. 471: 523-6 (2011).

 

Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Barretina J, Caponigro G, Cheung HW, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub TR, Dummer R, Weber B, Sellers WR, Schlegel R, Hahn WC, Garraway LA. COT/MAP3K8 drives resistance to selective B-RAF inhibition via MAPK pathway reactivation. Nature. 468: 968-72 (2010).

 

Taylor BS*, Schultz N*, Hieronymus H*, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL. Integrative genomic profiling of human prostate cancer Cancer Cell. 18:11-22 (2010).

 

* contributed equally to this work

 

King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 5: 524-6 (2009).

 

Du J, Bernasconi P, Clauser KR, Mani DR, Finn SP, Beroukhim R, Burns M, Julian B, Peng XP, Hieronymus H, Maglathlin RL, Lewis TA, Liau LM, Nghiemphu P, Mellinghoff IK, Louis DN, Loda M, Carr SA, Kung AL, Golub TR.   Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.   Nat Biotechnol. 27: 77-83 (2009). Epub 2008.

 

Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC,  Chiosis G, Golub TR.  Gene expression signature-based chemical genomic prediction identifies novel class of HSP90 pathway modulators.  Cancer Cell  10, 321-330 (2006).

 

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP., Subramanian A, Ross KN, Reich M , Hieronymus H, Wei G, Armstrong S., Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: Using Gene-expression Signatures to Connect Small Molecules, Genes and Disease. Science 313:1929-35 (2006).

 

Hieronymus H, Silver PA. A systems view of mRNP biology.  Genes Dev. 18, 2845-60 (2004).

 

Hieronymus H, Yu MC, Silver PA. Genome-wide mRNA surveillance is coupled to mRNA export.

Genes Dev. 18, 2652-62 (2004).

 

Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell 14, 427-39 (2004).

 

Hieronymus H and Silver PA. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet. 33, 155-61 (2003).

 

 

 

 

REFERENCES available on request