Haley Hieronymus

 

Memorial Sloan Kettering Cancer Center

1275 York Ave Box 20  ·  New York, NY 10065

   haley@metaphase.net   

 

 

 

EXPERIENCE

 

2008 – present     Senior Scientist, Memorial Sloan Kettering Cancer Center, New York, New York

                             Laboratory of Charles Sawyers

 

 

2005 – 2007        Post-doctoral research fellow, Laboratory of Todd Golub

Broad Institute, Massachusetts Institute of Technology and Harvard University

 

Research centered on nuclear hormone and kinase signaling and their interplay with the cellular chaperone machinery in hormone-mediated cancer

 

·  Demonstrated the ability  of gene expression-based analysis to predict and identify chemical activity

·  Identified a new class of HSP90 inhibitors through gene expression-based chemical genomic screening for androgen receptor signaling inhibitors

·  Developing gene expression signatures of kinase activation and their modulation by HSP90 and other inhibitors; includes creating 500 clone collection

 

 

1999 – 2004        Graduate student, Laboratory of Pamela Silver,  Department of Biological Chemistry and Molecular Pharmacology, Department of Systems Biology, Harvard Medical School

 

Ph.D. thesis focused on nuclear transport of mRNA and its integration with gene expression processes

 

·  Discovered the mRNA binding specificity of nuclear export factors;  characterized the whole-genome RNA-protein interactions involved in mRNA export

· Identified novel mRNA export factors through a systematic screen of all non-essential yeast genes

·  Described the coupling of mRNA export to DNA and RNA surveillance and mRNA degradation by two new mRNA export factors

 

1998 - 1999         Undergraduate thesis student, Laboratory of Adele Wolfson, Wellesley College 

Determined the kinetics and mechanism of calcium activation of thimet neuroendopeptidase.

 

 

Summer 1998       Undergraduate research fellow, Laboratory of Vishwanath Lingappa, UCSF

Examined the role and mechanism of apoptosis in heritable neurodegenerative prion disease.

 

 

EDUCATION

 

1999 - 2004         Harvard Medical School, Harvard University                                    Boston, MA

Ph.D. in Biological and Biomedical Sciences  GPA 3.85

 

1997- 1998          Oxford University                                                                        Oxford, England

Visiting student, Department of Biochemistry, junior year

 

1995 - 1999         Wellesley College                                                                             Wellesley, MA

B.A. in Biological Chemistry with honors, summa cum laude GPA 3.97

 

 

 

AWARDS AND GRANTS

 

2005                     Damon Runyon Postdoctoral Fellowship (accepted)

                             Life Sciences Research Fund Postdoctoral Fellowship

                             American Cancer Society Postdoctoral Fellowship

NIH Kirschstein NRSA Postdoctoral Fellowship

 

2003                     Harvard Fellowship finalist

 

1999                     Howard Hughes Medical Institute Predoctoral Fellowship (accepted)

National Science Foundation Graduate Fellowship

Karin Ippen-Ihler Prize in Chemistry for academic excellence & service

Election to Sigma Xi, national science and engineering honors society

Election to Phi Beta Kappa

 

1998                     Three Generations in Science Writing Award

 

 

 

PUBLICATIONS

 

King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 5: 524-6 (2009).

Du J, Bernasconi P, Clauser KR, Mani DR, Finn SP, Beroukhim R, Burns M, Julian B, Peng XP, Hieronymus H, Maglathlin RL, Lewis TA, Liau LM, Nghiemphu P, Mellinghoff IK, Louis DN, Loda M, Carr SA, Kung AL, Golub TR.   Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.   Nat Biotechnol. 27: 77-83 (2009). Epub 2008.

Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC,  Chiosis G, Golub TR.  Gene expression signature-based chemical genomic prediction identifies novel class of HSP90 pathway modulators.  Cancer Cell  10, 321-330 (2006).

 

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP., Subramanian A, Ross KN, Reich M , Hieronymus H, Wei G, Armstrong S., Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: Using Gene-expression Signatures to Connect Small Molecules, Genes and Disease. Science 313:1929-35 (2006).

 

Hieronymus H, Silver PA. A systems view of mRNP biology.  Genes Dev. 18, 2845-60 (2004).

 

Hieronymus H, Yu MC, Silver PA. Genome-wide mRNA surveillance is coupled to mRNA export.

Genes Dev. 18, 2652-62 (2004).

 

Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell 14, 427-39 (2004).

 

Hieronymus H and Silver PA. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet. 33, 155-61 (2003).

 

 

REFERENCES available on request