Haley Hieronymus
Memorial Sloan Kettering Cancer Center
1275 York Ave Box 20 · New York, NY 10065
haley@metaphase.net
EXPERIENCE
2008 – present Senior Scientist, Memorial Sloan Kettering Cancer Center, New York, New York
Laboratory of Charles Sawyers
2005 – 2007 Post-doctoral research fellow, Laboratory of Todd Golub
Broad Institute, Massachusetts Institute of Technology and Harvard University
Research centered on nuclear hormone and kinase signaling and their interplay with the cellular chaperone machinery in hormone-mediated cancer
· Demonstrated the ability of gene expression-based analysis to predict and identify chemical activity
· Identified a new class of HSP90 inhibitors through gene expression-based chemical genomic screening for androgen receptor signaling inhibitors
· Developing gene expression signatures of kinase activation and their modulation by HSP90 and other inhibitors; includes creating 500 clone collection
1999 – 2004 Graduate student, Laboratory of Pamela Silver, Department of Biological Chemistry and Molecular Pharmacology, Department of Systems Biology, Harvard Medical School
Ph.D. thesis focused on nuclear transport of mRNA and its integration with gene expression processes
· Discovered the mRNA binding specificity of nuclear export factors; characterized the whole-genome RNA-protein interactions involved in mRNA export
· Identified novel mRNA export factors through a systematic screen of all non-essential yeast genes
· Described the coupling of mRNA export to DNA and RNA surveillance and mRNA degradation by two new mRNA export factors
1998 - 1999 Undergraduate thesis student, Laboratory of Adele Wolfson, Wellesley College
Determined the kinetics and mechanism of calcium activation of thimet neuroendopeptidase.
Summer 1998 Undergraduate research fellow, Laboratory of Vishwanath Lingappa, UCSF
Examined the role and mechanism of apoptosis in heritable neurodegenerative prion disease.
EDUCATION
1999 - 2004 Harvard Medical School, Harvard University Boston, MA
Ph.D. in Biological and Biomedical Sciences GPA 3.85
1997- 1998 Oxford University Oxford, England
Visiting student, Department of Biochemistry, junior year
1995 - 1999 Wellesley College Wellesley, MA
B.A. in Biological Chemistry with honors, summa cum laude GPA 3.97
AWARDS AND GRANTS
2005 Damon Runyon Postdoctoral Fellowship (accepted)
Life Sciences Research Fund Postdoctoral Fellowship
American Cancer Society Postdoctoral Fellowship
NIH Kirschstein NRSA Postdoctoral Fellowship
2003 Harvard Fellowship finalist
1999 Howard Hughes Medical Institute Predoctoral Fellowship (accepted)
National Science Foundation Graduate Fellowship
Karin Ippen-Ihler Prize in Chemistry for academic excellence & service
Election to Sigma Xi, national science and engineering honors society
Election to Phi Beta Kappa
1998 Three Generations in Science Writing Award
PUBLICATIONS
King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 5: 524-6 (2009).
Du J, Bernasconi P, Clauser KR, Mani DR, Finn SP, Beroukhim R, Burns M, Julian B, Peng XP, Hieronymus H, Maglathlin RL, Lewis TA, Liau LM, Nghiemphu P, Mellinghoff IK, Louis DN, Loda M, Carr SA, Kung AL, Golub TR. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nat Biotechnol. 27: 77-83 (2009). Epub 2008.
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies novel class of HSP90 pathway modulators. Cancer Cell 10, 321-330 (2006).
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP., Subramanian A, Ross KN, Reich M , Hieronymus H, Wei G, Armstrong S., Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: Using Gene-expression Signatures to Connect Small Molecules, Genes and Disease. Science 313:1929-35 (2006).
Hieronymus H, Silver PA. A systems view of mRNP biology. Genes Dev. 18, 2845-60 (2004).
Hieronymus H, Yu MC, Silver PA. Genome-wide mRNA surveillance is coupled to mRNA export.
Genes Dev. 18, 2652-62 (2004).
Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell 14, 427-39 (2004).
Hieronymus H and Silver PA. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet. 33, 155-61 (2003).
REFERENCES available on request